Browsing Ciències de la Salut by Author "Herrero, Laura"

Now showing items 1-5 of 5

    • Central regulation of brown fat thermogenesis in response to saturated or unsaturated long-chain fatty acids 

      Fosch Masllovet, Anna; Rodríguez García, Maria; Miralpeix , Cristina; Zagmutt, Sebastián; Larrañaga Fernandez, Maite; Reguera, Ana Cristina; Garcia-Chica, Jesus; Herrero, Laura; Serra, Dolors; Casals, Nuria; Rodriguez-Rodriguez, Rosalia (International Journal of Molecular Sciences, 2023)
      Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance, and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on hypothalamic-brown ...

    • CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst 

      Zagmutt, Sebastián; Mera, Paula; González García, Ismael; Ibeas, Kevin; Romero, María del Mar; Obri, Arnaud; Martin, Beatriz; Esteve Codina, Anna; Soler Vázquez, M. Carmen; Bastias Pérez, Marianela; Cañes, Laia; Augé, Elisabeth; Pelegri, Carme; Vilaplana, Jordi; Ariza, Xavier; García, Jordi; Martinez González, José; Casals, Núria; López, Miguel; Palmiter, Richard; Sanz, Elisenda; Quintana, Albert; Herrero, Laura; Serra, Dolors (Biology of Sex Differences, 2023)
      Background: Fatty acid metabolism in the hypothalamus has an important role in food intake, but its specific role in AgRP neurons is poorly understood. Here, we examined whether carnitinea palmitoyltransferase ...

    • Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice 

      Soler Vázquez, M. Carmen; Romero, María del Mar; Todorcevic, Marijana; Delgado, Katia; Calatayud, Carles; Benitez Amaro, Aleyda; La Chica Lhoëst, Maria Teresa; Mera, Paula; Zagmutt, Sebastián; Bastías Pérez, Marianela; Ibeas, Kevin; Casals, Núria; Escolà Gil, Joan Carles; Llorente Cortés, Vicenta; Consiglio, Antonella; Serra, Dolors; Herrero, Laura (Metabolic Engineering, 2023-05)
      Obesity and its associated metabolic comorbidities are a rising global health and social issue, with novel therapeutic approaches urgently needed. Adipose tissue plays a key role in the regulation of ...

    • Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance 

      Garcia-Chica, Jesús; Paraiso, West Kristian; Zagmutt, Sebastián; Fosch, Anna; Reguera, Ana Cristina; Alzina, Sara; Sánchez-García, Laura; Fukushima, Shigeto; Toh, Kazuko; Casals, Núria; Serra, Dolors; Herrero, Laura; Garcia Gomez, Jordi; Kataoka, Kazunori; Ariza, Xavier; Quader, Sabina; Rodriguez-Rodriguez, Rosalia (Biomaterials Science, 2023)
      Targeting brain lipid metabolism is a promising strategy to regulate the energy balance and fight metabolic diseases such as obesity. The development of stable platforms for selective delivery of drugs, ...

    • To be or not to be a fat burner, that is the question for cpt1c in cancer cells 

      Fadó Andrés, Rut; Zagmutt, Sebastián; Herrero, Laura; Muley, Helena; Rodriguez-Rodriguez, Rosalia; Bi, Huichang; Serra, Dolors; Casals, Nuria (Cell Death & Disease, 2023)
      There is an urgent need to identify reliable genetic biomarkers for accurate diagnosis, prognosis, and treatment of different tumor types. Described as a prognostic marker for many tumors is the neuronal ...