Now showing items 21-40 of 710

    • The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays 

      Vainshtein, Yevhen; Sanchez, Mayka; Brazma, Alvis; W. Hentze, Matthias; Dandekar, Thomas; Muckenthaler, Martina U. (BMC Bioinformatics, 2010)
      Background: Gene expression studies greatly contribute to our understanding of complex relationships in gene regulatory networks. However, the complexity of array design, production and manipulations ...
    • Simulation methods with extended stability for stiff biochemical Kinetics 

      Rué, Pau; Villà-Freixa, Jordi; Burrage, Kevin (BMC Systems Biology, 2010)
      Background: With increasing computer power, simulating the dynamics of complex systems in chemistry and biology is becoming increasingly routine. The modelling of individual reactions in (bio)chemical ...
    • Differential HMG‐CoA lyase expression in human tissues provides clues about 3‐hydroxy‐3‐methylglutaric aciduria 

      Puisac, Beatriz; Arnedo, María; Casale, César H.; Ribate, María Pilar; Castiella, Tomás; Ramos, Feliciano J.; Ribes, Antònia; Pérez-Cerdá, Celia; Casals i Farré, Núria; Hegardt, Fausto G.; Pié, Juan (Journal of Inherited Metabolic Disease, 2010)
      3‐Hydroxy‐3‐methylglutaric aciduria is a rare human autosomal recessive disorder caused by deficiency of 3‐hydroxy‐3‐methylglutaryl CoA lyase (HL). This mitochondrial enzyme catalyzes the common final ...
    • Effectiveness of a Surgery Admission Unit for patients undergoing major elective surgery in a tertiary university hospital 

      Ortiga Fontgivell, Berta; Capdevila, Cristina; Salazar Soler, Albert; Viso, M.F.; Bartolomé Sarvisé, Carlos; Corbella Virós, Xavier (BMC Health Services Research, 2010-01-22)
      Background: The increasing demand on hospitalisation, either due to elective activity from the waiting lists or due to emergency admissions coming from the Emergency Department (ED), requires looking ...
    • The transcriptional network activated by Cln3 cyclin at the G1-to-S transition of the yeast cell cycle 

      Ferrezuelo, Francisco; Colomina, Neus; Futcher, Bruce; Aldea Malo, Martí (Genome Biology, 2010-06-23)
      Background: The G1-to-S transition of the cell cycle in the yeast Saccharomyces cerevisiae involves an extensive transcriptional program driven by transcription factors SBF (Swi4-Swi6) and MBF (Mbp1-Swi6). ...
    • SIREs: searching for iron-responsive elements 

      Campillos, Monica; Cases, Ildefonso; Hentze, Matthias W.; Sanchez, Mayka (Nucleic Acids Research, 2010-07)
      The iron regulatory protein/iron-responsive element regulatory system plays a crucial role in the post-transcriptional regulation of gene expression and its disruption results in human disease. IREs are ...
    • A nucleotide-based drug protects against glutamate- and MPP+ -induced neurotoxicity 

      Gella Concustell, Alejandro; Martiáñez Canales, Tània; Lamarca Dams, Aloa; Gutierrez, Cristina; Durany, Nuria; Casals i Farré, Núria (Neuroscience & Medicine, 2011)
      Nucleo CMP Forte® is a nucleotide-based drug consisting of cytidinemonophosphate, uridinemonophosphate, uridin-ediphosphate and uridinetriphosphate. It has been prescribed for peripheral nervous system ...
    • Impacto de la violencia colectiva en la salud. Resultados del estudio ISAVIC en el País Vasco 

      Larizgoitia, Itziar; Izarzugaza, Isabel; Iraurgi, Ioseba; Ballesteros, Javier; Forero, Carlos G.; Markez, Iñaki; Alonso, Jordi; ISAVIC (Gaceta Sanitaria, 2011)
      Objetivo: A pesar de la ubicuidad de la violencia y de su posible importancia para la salud de las personas y las colectividades, su papel y mecanismos de acción en este sentido no están apenas analizados. ...
    • Knowledge management for systems biology a general and visually driven framework applied to translational medicine 

      Maier, Dieter; Kalus, Wenzel; Wolff, Martin; Kalko, Susana G.; Roca, Josep; Marin de Mas, Igor; Turan, Nil; Cascante, Marta; Falciani, Francesco; Hernandez, Miguel; Villà-Freixa, Jordi; Losko, Sascha (BMC Systems Biology, 2011)
      Background: To enhance our understanding of complex biological systems like diseases we need to put all of the available data into context and use this to detect relations, pattern and rules which allow ...
    • Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins 

      Sanchez, Mayka; Galy, Bruno; Schwanhaeusser, Bjoern; Blake, Jonathon; Bähr-Ivacevic, Tomi; Benes, Vladimir; Selbach, Matthias; Muckenthaler, Martina U.; Hentze, Matthias W. (Blood, 2011)
      Iron regulatory proteins (IRPs) 1 and 2 are RNA-binding proteins that control cellular iron metabolism by binding to conserved RNA motifs called iron-responsive elements (IREs). The currently known ...
    • Exploring the link between MORF4L1 and risk of breast cancer 

      Martrat, Griselda; Maxwell, Christopher A.; Tominaga, Emiko; Porta-de-la-Riva, Montserrat; Bonifaci, Núria; Gómez-Baldó, Laia; Bogliolo, Massimo; Lázaro, Conxi; Blanco, Ignacio; Brunet, Joan; Aguilar, Helena; Fernández-Rodríguez, Juana; Seal, Sheila; Renwick, Anthony; Rahman, Nazneen; Kühl, Julia; Neveling, Kornelia; Schindler, Detlev; Ramírez, María J.; Castellà, María; Hernández, Gonzalo; EMBRACE; Easton, Douglas F.; Peock, Susan; Cook, Margaret; Oliver, Clare T.; Frost, Debra; Platte, Radka; Evans, D. Gareth; Lalloo, Fiona; Eeles, Rosalind; Izatt, Louise; Chu, Carol; Davidson, Rosemarie; Ong, Kai-Ren; Cook, Jackie; Douglas, Fiona; Hodgson, Shirley; Brewer, Carole; Morrison, Patrick J.; Porteous, Mary; Peterlongo, Paolo; Manoukian, Siranoush; Peissel, Bernard; Zaffaroni, Daniela; Roversi, Gaia; Barile, Monica; Viel, Alessandra; Pasini, Barbara; Ottini, Laura; Putignano, Anna Laura; Savarese, Antonella; Bernard, Loris; Radice, Paolo; Healey, Sue; Spurdle, Amanda; Chen, Xiaoqing; Beesley, Jonathan; kConFab; Rookus, Matti A.; Verhoef, Senno; Tilanus-Linthorst, Madeleine A.; Vreeswijk, Maaike P.; Asperen, Christi J.; Bodmer, Danielle; Ausems, Margreet GEM; Van Os, Theo A.; Blok, Marinus J.; Meijers-Heijboer, Hanne EJ; Hogervorst, Frans BL; HEBON; Goldgar, David E.; Buys, Saundra; John, Esther M.; Miron, Alexander; Southey, Melissa; Daly, Mary B.; BCFR; SWE-BRCA; Harbst, Katja; Borg, Åke; Rantala, Johanna; Barbany-Bustinza, Gisela; Ehrencrona, Hans; Stenmark-Askmalm, Marie; Kaufman, Bella; Laitman, Yael; Milgrom, Roni; Friedman, Eitan; Domchek, Susan M.; Nathanson, Katherine L.; Rebbeck, Timothy R.; Johannsson, Oskar Thor; Couch, Fergus J.; Wang, Xianshu; Fredericksen, Zachary; Cuadras, Daniel; Moreno, Víctor; Pientka, Friederike K.; Depping, Reinhard; Caldés, Trinidad; Osorio, Ana; Benítez, Javier; Bueren, Juan; Heikkinen, Tuomas; Nevanlinna, Heli; Hamann, Ute; Torres, Diana; Caligo, Maria Adelaide; Godwin, Andrew K.; Imyanitov, Evgeny N.; Janavicius, Ramunas; GEMO Study Collaborators; Sinilnikova, Olga M.; Stoppa-Lyonnet, Dominique; Mazoyer, Sylvie; Verny-Pierre, Carole; Castera, Laurent; De Pauw, Antoine; Bignon, Yves-Jean; Uhrhammer, Nancy; Peyrat, Jean-Philippe; Vennin, Philippe; Fert Ferrer, Sandra; Collonge-Rame, Marie-Agnès; Mortemousque, Isabelle; McGuffog, Lesley; Chenevix-Trench, Georgia; Pereira-Smith, Olivia M.; Antoniou, Antonis C.; Cerón, Julián; Tominaga, Kaoru; Surrallés, Jordi; Pujana, Miguel Angel (Breast Cancer Research, 2011)
      Introduction: Proteins encoded by Fanconi anemia (FA) and/or breast cancer (BrCa) susceptibility genes cooperate in a common DNA damage repair signaling pathway. To gain deeper insight into this pathway ...
    • Missense SLC25A38 variations play an important role in autosomal recessive inherited sideroblastic anemia 

      Kannengiesser, Caroline; Sanchez, Mayka; Sweeney, Marion; Hetet, Gilles; Kerr, Briedgeen; Moran, Erica; Fuster Soler, Jose L.; Maloum, Karim; Matthes, Thomas; Oudot, Caroline; Lascaux, Axelle; Pondarré, Corinne; Sevilla Navarro, Julian; Vidyatilake, Sudharma; Beaumont, Carole; Grandchamp, Bernard; May, Alison (Haematologica, 2011)
      Congenital sideroblastic anemias are rare disorders with several genetic causes; they are characterized by erythroblast mitochondrial iron overload, differ greatly in severity and some occur within a ...
    • Traumatismes desapercebuts en un adolescent amb intoxicació etílica aguda: a propòsit d'un cas 

      Alsina Casanova, Miguel; Trenchs Sainz de la Maza, Victoria; Sarmiento Martínez, M.; Luaces Cubells, Carles (Pediatria catalana: butlletí de la Societat Catalana de Pediatria, 2011)
      Introducció. Són ben coneguts els efectes deleteris directament associats a la intoxicació etílica aguda, així com la seva associació amb factors comòrbids, com el consum simultani d'altres substàncies ...
    • Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders 

      Mingorance, Carmen; Rodríguez-Rodríguez, Rosalía; Justo, María Luisa; Álvarez de Sotomayor, María; Dolores Herrera, María (Vascular Health and Risk Management, 2011-03-28)
      Acetyl-L-carnitine (ALC) and propionyl-L-carnitine (PLC) are two naturally occurring carnitine derivates formed by carnitine acetyltransferase. The beneficial cardiovascular effects of ALC and PLC have ...
    • Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12 

      Badiola, Nahuai; Penas, Clara; Miñano Molina, Alfredo Jesús; Barneda-Zahonero, Bruna; Fadó Andrés, Rut; Sánchez-Opazo, G.; Comella, Joan X.; Sabrià, Josefa; Zhu, Chuanshuai; Blomgren, Klas; Casas, Caty; Rodríguez-Álvarez, José (Cell Death and Disease, 2011-04-28)
      Disturbance of calcium homeostasis and accumulation of misfolded proteins in the endoplasmic reticulum (ER) are considered contributory components of cell death after ischemia. However, the signal-transducing ...
    • Soluble oligomers of amyloid-β peptide disrupt Membrane trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction 

      Miñano Molina, Alfredo Jesús; España, Judit; Martín, Elsa; Barneda-Zahonero, Bruna; Fadó Andrés, Rut; Solé, Montse; Trullás, Ramón; Saura, Carlos A.; Rodríguez-Álvarez, José (Journal of Biological Chemistry, 2011-08-05)
      β-Amyloid (Aβ), a peptide generated from the amyloid precursor protein, is widely believed to underlie the pathophysiology of Alzheimer disease (AD). Emerging evidences suggest that soluble Aβ oligomers ...
    • Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol 

      Arnedo, María; Menao, Sebastián; Puisac, Beatriz; Teresa-Rodrigo, María E.; Gil-Rodríguez, María C.; López-Viñas, Eduardo; Gómez-Puertas, Paulino; Casals i Farré, Núria; Casale, César H.; Hegardt, Fausto G.; Pié, Juan (Journal of Lipid Research, 2012)
      A novel lyase activity enzyme is characterized for the first time: HMG-CoA lyase-like1 (er-cHL), which is a close homolog of mitochondrial HMG-CoA lyase (mHL). Initial data show that there are nine ...
    • Factors influencing burden among non-professional immigrant caregivers: a case-control study 

      Gallart Fernández-Puebla, Alberto; Cruz, Félix; Zabalegui, Adelaida (Journal of Advanced Nursing, 2012)
      Aim: To identify factors related to the burden that is experienced by untrained immigrant caregivers. Background: There is growing concern about how to provide the care required by an ageing population. ...
    • Policitemia en el recien nacido 

      Casanova, Miguel; Strad, Joiner (Anales de Pediatría Continuada, 2012)
    • Polymeric additives to enhance the functional properties of calcium phosphate cements 

      Pérez Antoñanzas, Roman; Hae-Won, Kim; Ginebra Molins, Maria Pau (2012-03-20)
      The vast majority of materials used in bone tissue engineering and regenerative medicine are based on calcium phosphates due to their similarity with the mineral phase of natural bone. Among them, calcium ...