Now showing items 85-104 of 710

    • Boceprevir plus pegylated interferon/ribavirin to re-treat hepatitis C virus genotype 1 in HIV–HCV co-infected patients: final results of the Spanish BOC HIV–HCV Study 

      Laguno, M.; Von Wichmann, M. A.; Van den Eynde, E.; Navarro, J.; Cifuentes, Carmen; Murillas, J.; Veloso, S.; Martínez-Rebollar, M.; Guardiola, J.M.; Jou, A.; Gómez-Sirvent, J.L.; Cervantes, M.; Pineda, J.A.; López-Calvo, S.; Carrero, Ana; Montes, M.L.; Deig, E.; Tapiz, A.; Ruiz-Mesa, J.D.; Cruceta, A.; de Lazzari, E.; Mallolas, Josep (International Journal of Infectious Diseases, 2016-12)
      Introduction: Boceprevir (BOC) was one of the first oral inhibitors of hepatitis C virus (HCV) NS3 protease to be developed. This study assessed the safety and efficacy of BOC + pegylated interferon-α ...
    • Bone mineral density, pulmonary function, chronological age, and age at diagnosis in children and adolescents with cystic fibrosis 

      Donadio, Márcio V.F.; De Souza, Guilherme C.; Tiecher, Gabriele; Heinzmann-Filho, João P.; Paim, Taísa F.; Hommerding, Patrícia X.; Marosticaf, Paulo J.C. (Jornal de Pediatria, 2013)
      Objective: To assess bone mineral density in patients with cystic fibrosis (CF), and to correlate it with possible intervening variables. Methods: Children and adolescents diagnosed with CF, aged 6 to ...
    • Bone morphogenetic protein-6 promotes cerebellar granule neurons survival by activation of the MEK/ERK/CREB pathway 

      Barneda-Zahonero, Bruna; Miñano Molina, Alfredo Jesús; Badiola, Nahuai; Fadó Andrés, Rut; Xifró Collsamata, Xavier; Saura, Carlos A.; Rodríguez Álvarez, José (2009-12-15)
      Bone morphogenetic proteins (BMPs) have been implicated in the generation and postnatal differentiation of cerebellar granule cells (CGCs). Here, we examined the eventual role of BMPs on the survival ...
    • Breast cancer-related lymphoedema: risk factors and prediction model 

      Martínez-Jaimez, Patricia; Armora Verdú, Miriam; Garcia Forero, Carlos; Álvarez Salazar, Samantha; Fuster-Linares, Pilar; Monforte-Royo, Cristina; Masia, Jaume (Journal of Advanced Nursing, 2021)
      Aims: To identify the risk factors for lymphoedema following axillary lymph node dissection (ALND) in a European sample and to propose a lymphoedema prediction model for this population. Design: Predictive ...
    • Bullous henoch-schönlein purpura: a case series 

      Paloni, Giulia; Silecchia, Valeria; Berti, Irene; Tagarelli, Arianna; Mazzoni, Elisa; Lambertini, Andrea; Valerio, Enrico; Grimalt Santacana, Ramon; Cutrone, Mario (Journal of Respiratory Research, 2019-12)
      Henoch-Schönlein purpura (HSP) represents the most common vasculitis in children. Typically, HSP manifests with palpable purpura and edema, usually following an urticarial or erythematous maculopapular ...
    • Burden of disease attributable to second-hand smoke exposure: a systematic review 

      Carreras, Giulia; Lugo, Alessandra; Gallus, Silvano; Cortini, Barbara; Fernández, Esteve; López, Maria José; Soriano, Joan B.; López Nicolás, Ángel; Semple, Sean; Gorini, Giuseppe; TackSHS Project Investigators (Preventive Medicine, 2019-12)
      Our aim was to provide a systematic review of studies on the burden of disease due to second-hand smoke (SHS) exposure, reviewing methods, exposure assessment, diseases causally linked to SHS, health ...
    • Caracterización del microbioma nasofaríngeo en pacientes con enfermedad de Kawasaki 

      Sánchez-Manubens, Judith; Henares, Desirée; Muñoz-Almagro, Carmen; Brotons, Pedro; Timoneda, Natàlia; Antón, Jordi (2022)
      Introducción: La etiología de la enfermedad de Kawasaki (EK) sigue siendo desconocida. Varios estudios han relacionado el microbioma humano con algunas enfermedades. Sin embargo, los estudios sobre el ...
    • Cardiopulmonary coupling indices to assess weaning readiness from mechanical ventilation 

      Armañac-Julián, Pablo; Hernando, David; Lázaro, Jesús; De Haro, Candelaria; Magrans, Rudys; Morales, John; Moeyersons, Jonathan; Sarlabous, Leonardo; López-Aguilar, Josefina; Subirà Cuyàs, Carles; Fernández, Rafael; Orini, Michele; Laguna, Pablo; Varon, Carolina; Gil, Eduardo; Bailón, Raquel; Blanch, Lluís (Scientific Reports, 2021)
      The ideal moment to withdraw respiratory supply of patients under Mechanical Ventilation at Intensive Care Units (ICU), is not easy to be determined for clinicians. Although the Spontaneous Breathing ...
    • Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status 

      Miralpeix Monclús, Cristina; Reguera, Ana Cristina; Fosch, Anna; Casas, Maria; Lillo, Jaume; Navarro, Gemma; Franco, Rafael; Casas, Josefina; Alexander, Stephen P.H.; Casals i Farré, Núria; Rodríguez-Rodríguez, Rosalía (British Journal of Pharmacology, 2021-01)
      Background and Purpose: The enzyme α/β‐hydrolase domain containing 6 (ABHD6), a new member of the endocannabinoid system, is a promising therapeutic target against neuronal‐related diseases. However, ...
    • Catheter-directed therapies in patients with pulmonary embolism: predictive factors of in-hospital mortality and long-term follow-up 

      Ribas, Jesús; Valcárcel, Joana; Alba, Esther; Ruíz, Yolanda; Cuartero, Daniel; Iriarte, Adriana; Mora-Luján, José María; Huguet, Marta; Cerdà, Pau; Martínez-Yélamos, Sergio; Corbella Virós, Xavier; Santos, Salud; Riera-Mestre, Antoni (Journal of Clinical Medicine, 2021)
      Background: Catheter-directed therapies (CDT) may be considered for selected patients with pulmonary embolism (PE); (2) Methods: Retrospective observational study including all consecutive patients with ...
    • CDK-mediated Yku80 phosphorylation regulates the balance between non-homologous end joining (NHEJ) and homologous directed recombination (HDR) 

      Carballar, Reyes; Martínez-Láinez, Joan M.; Samper, Bàrbara; Bru, Samuel; Bállega, Elisabet; Mirallas, Oriol; Ricco, Natalia; Clotet, Josep; Jiménez, Javier (Journal of Molecular Biology, 2020)
      There are two major pathways for repairing DNA double-strand breaks (DSBs): homologous directed recombination (HDR) and non-homologous end-joining (NHEJ). While NHEJ functions throughout the cell cycle, ...
    • CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation 

      Quandt, Eva; Masip, Núria; Hernández-Ortega, Sara; Sánchez-Botet, Abril; Gasa, Laura; Fernández-Elorduy, Ainhoa; Plutta, Sara; Martínez-Láinez, Joan Marc; Bru, Samuel; Munoz-Torres, Pau M.; Floor, Martin; Villà-Freixa, Jordi; Morris, May C.; Vidal, August; Villanueva, Alberto; Clotet, Josep; Ribeiro, Mariana P. C. (Molecular Oncology, 2023)
      Cyclin-dependent kinases (CDKs), together with their cyclin partners, are the master cell cycle regulators. Remarkably, the cyclin family was extended to include atypical cyclins, characterized by ...
    • Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance 

      Contreras, Cristina; González-García, Ismael; Martínez-Sánchez, Noelia; Seoane-Collazo, Patricia; Jacas i Mateu, Jordi; Morgan, Donald A.; Serra, Dolors; Gallego, Rosalía; Gonzalez, Francisco; Casals i Farré, Núria; Nogueiras, Rubén; Rahmouni, Kamal; Diéguez, Carlos; López, Miguel (Cell Reports, 2014-10)
      Hypothalamic endoplasmic reticulum (ER) stress is a key mechanism leading to obesity. Here, we demonstrate that ceramides induce lipotoxicity and hypothalamic ER stress, leading to sympathetic inhibition, ...
    • Central regulation of brown fat thermogenesis in response to saturated or unsaturated long-chain fatty acids 

      Fosch Masllovet, Anna; Rodríguez García, Maria; Miralpeix , Cristina; Zagmutt, Sebastián; Larrañaga Fernandez, Maite; Reguera, Ana Cristina; Garcia-Chica, Jesus; Herrero, Laura; Serra, Dolors; Casals, Nuria; Rodriguez-Rodriguez, Rosalia (International Journal of Molecular Sciences, 2023)
      Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance, and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on hypothalamic-brown ...
    • Centromeric signaling proteins boost G1 cyclin degradation and modulate cell size in budding yeast 

      Martínez-Láinez, Joan M.; Moreno, David F.; Parisi, Eva; Clotet Erra, Josep; Aldea Malo, Martí (PLoS Biology, 2018-08-06)
      Cell size scales with ploidy in a great range of eukaryotes, but the underlying mechanisms remain unknown. Using various orthogonal single-cell approaches, we show that cell size increases linearly ...
    • Cerebral oximetry monitoring in extremely preterm infants 

      Hansen, Mathias L.; Pellicer, Adelina; Hyttel-Sørensen, Simon; Ergenekon, Ebru; Szczapa, Tomasz; Hagmann, Cornelia; Naulaers, Gunnar; Mintzer, Jonathan; Fumagalli, Monica; Dimitriou, Gabriel; Dempsey, Eugene; Tkaczyk, Jakub; Cheng, Guoqiang; Fredly, Siv; Heuchan, Anne M.; Pichler, Gerhard; Fuchs, Hans; Nesargi, Saudamini; Hahn, Gitte H.; Piris-Borregas, Salvador; Širc, Jan; Alsina-Casanova, Miguel; Stocker, Martin; Ozkan, Hilal; Sarafidis, Kosmas; Hopper, Andrew O.; Karen, Tanja; Rzepecka-Weglarz, Beata; Oguz, Serife S.; Arruza, Luis; Memisoglu, Asli C.; del Rio Florentino, Ruth; Baserga, Mariana; Maton, Pierre; Truttmann, Anita C.; de las Cuevas, Isabel; Agergaard, Peter; Zafra, Pamela; Bender, Lars; Lauterbach, Ryszard; Lecart, Chantal; de Buyst, Julie; El-Khuffash, Afif; Curley, Anna; Vaccarello, Olalla O.; Miletin, Jan; Papathoma, Evangelia; Vesoulis, Zachary; Vento, Giovanni; Cornette, Luc; Lopez, Laura S.; Yasa, Beril; Klamer, Anja; Agosti, Massimo; Baud, Olivier; Mastretta, Emmanuele; Cetinkaya, Merih; McCall, Karen; Zeng, Shujuan; Hatzidaki, Eleftheria; Bargiel, Agata; Marciniak, Sylwia; Gao, Xiaoyan; Huijia, Lin; Chalak, Lina; Yang, Ling; Rao, Shashidhar A.; Xu, Xin; Gonzalez, Begoña L.; Wilinska, Maria; Yin, Zhaoqing; Sadowska-Krawczenko, Iwona; Serrano-Viñuales, Itziar; Krolak-Olejnik, Barbara; Ybarra, Marta M.; Morales-Betancourt, Catalina; Korček, Peter; Palacio, Marta Teresa; Mosca, Fabio; Hergenhan, Anja; Koksal, Nilgun; Tsoni, Konstantia; Kadri, Munaf M.; Knöpfli, Claudia; Rafinska-Wazny, Elzbieta; Akin, Mustafa S.; Nordvik, Tone; Peng, Zhang; Kersin, Sinem G.; Thewissen, Liesbeth; Alarcon, Ana; Healy, David; Urlesberger, Berndt; Baş, Münevver; Baumgartner, Jana; Skylogianni, Eleni; Karadyova, Veronika; Valverde, Eva; Bergon-Sendin, Elena; Kucera, Jachym; Pisoni, Silvia; Wang, Le; Smits, Anne; Sanchez-Salmador, Rebeca; Rasmussen, Marie I.; Olsen, Markus H.; Jensen, Aksel K.; Gluud, Christian; Jakobsen, Janus C.; Greisen, Gorm (The New England Journal of Medicine, 2023)
      BACKGROUND: The use of cerebral oximetry monitoring in the care of extremely preterm infants is increasing. However, evidence that its use improves clinical outcomes is lacking.: METHODS: In this ...
    • Cerebrospinal fluid neopterin as a biomarker of neuroinflammatory diseases 

      Molero‑Luis, Marta; Casas-Alba, Didac; Orellana, Gabriela; Ormazabal, Aida; Sierra, Cristina; Oliva, Clara; Valls, Anna; Velasco, Jesus; Launes, Cristian; Cuadras, Daniel; Pérez‑Dueñas, Belén; Jordan, Iolanda; Cambra, Francisco J.; Ortigoza‑Escobar, Juan D.; Muñoz-Almagro, Carmen; Garcia‑Cazorla, Angels; Armangué, Thais; Artuch, Rafael (Scientific Reports, 2020)
      The elevation of neopterin in cerebrospinal fluid (CSF) has been reported in several neuroinflammatory disorders. However, it is not expected that neopterin alone can discriminate among different ...
    • Challenges for hospital management in supporting nurses to deliver humanized care 

      Martin-Ferreres, Maria Luisa; Wennberg-Capellades, Laia; Rodríguez Higueras, Encarnación; Llauradó Serra, Mireia; De Juan Pardo, Mª Ángeles (Nursing Inquiry, 2021)
      Hospitals are paying increasing attention to the delivery of humanized care. The purpose of this study was to explore from the nursing perspective what hospital managers might do to facilitate this. A ...
    • Challenges in using both eyes of the same patient when evaluating the results after implantation of intrastromal corneal ring segments 

      Lamarca Mateu, José; Salvador-Culla, Borja; Santos, Cristina; I Barraquer, Rafael (Acta Ophthalmologica, 2020)
      Purpose: To assess correlation between results from both eyes of the same patient after implantation of intrastromal corneal ring segments (ICRS) and define whether they can be used together in clinical ...
    • Changes in invasive pneumococcal disease caused by streptococcus pneumoniae serotype 1 following introduction of PCV10 and PCV13: findings from the PSERENADE project 

      Bennett, Julia C.; Hetrich, Marissa K.; Garcia Quesada, Maria; Sinkevitch, Jenna N.; Deloria Knoll, Maria; Feikin, Daniel R.; Zeger, Scott L.; Kagucia, Eunice W.; Cohen, Adam L.; Ampofo, Krow; Brandileone, Maria-Cristina; Bruden, Dana; Camilli, Romina; Castilla, Jesús; Chan, Guanhao; Cook, Heather; Cornick, Jennifer E.; Dagan, Ron; Dalby, Tine; Danis, Kostas; De Miguel, Sara; De Wals, Philippe; Desmet, Stefanie; Georgakopoulou, Theano; Gilkison, Charlotte; Grgic-Vitek, Marta; Hammitt, Laura L.; Hilty, Markus; Ho, Pak-Leung; Jayasinghe, Sanjay; Kellner, James D.; Kleynhans, Jackie; Knol, Mirjam J.; Kozakova, Jana; Kristinsson, Karl G.; Ladhani, Shamez N.; MacDonald, Laura; Mackenzie, Grant A.; Mad’arová, Lucia; McGeer, Allison; Mereckiene, Jolita; Morfeldt, Eva; Mungun, Tuya; Muñoz-Almagro, Carmen; Nuort, J. Pekka; Paragi, Metka; Pilishvili, Tamara; Puentes, Rodrigo; Saha, Samir K.; Sahu Khan, Aalisha; Savrasova, Larisa; Scott, J. Anthony; Skoczynska, Anna; Suga, Shigeru; Van Der Linden, Mark; Verani, Jennifer R.; Von Gottberg, Anne; Winje, Brita A.; Yildirim, Inci; Zerouali, Khalid; Hayford, Kyla; PSERENADE Team (Microorganisms, 2021)
      Streptococcus pneumoniae serotype 1 (ST1) was an important cause of invasive pneumococcal disease (IPD) globally before the introduction of pneumococcal conjugate vaccines (PCVs) containing ST1 antigen. ...