Browsing Ciències de la Salut by Title

Now showing items 154-173 of 723

    • CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst 

      Zagmutt, Sebastián; Mera, Paula; González García, Ismael; Ibeas, Kevin; Romero, María del Mar; Obri, Arnaud; Martin, Beatriz; Esteve Codina, Anna; Soler Vázquez, M. Carmen; Bastias Pérez, Marianela; Cañes, Laia; Augé, Elisabeth; Pelegri, Carme; Vilaplana, Jordi; Ariza, Xavier; García, Jordi; Martinez González, José; Casals, Núria; López, Miguel; Palmiter, Richard; Sanz, Elisenda; Quintana, Albert; Herrero, Laura; Serra, Dolors (Biology of Sex Differences, 2023)
      Background: Fatty acid metabolism in the hypothalamus has an important role in food intake, but its specific role in AgRP neurons is poorly understood. Here, we examined whether carnitinea palmitoyltransferase ...

    • Cpt1c downregulation causes plasma membrane remodelling and anthracycline resistance in breast cancer 

      Muley, Helena; Valencia, Karmele; Casas, Josefina; Moreno, Bea; Botella, Luis; Lecanda, Fernando; Fadó, Rut; Casals, Núria (International Journal of Molecular Sciences, 2023)
      Breast cancer (BC) is the most common malignancy in women worldwide. While the main systemic treatment option is anthracycline-containing chemotherapy, chemoresistance continues to be an obstacle to ...

    • CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity 

      Rodríguez-Rodríguez, Rosalía; Miralpeix Monclús, Cristina; Fosch, Anna; Pozo Ariza, Macarena; Calderón-Domínguez, María; Perpinyà, Xavier; Vellvehí, Miquel; López, Miguel; Herrero Rodríguez, Laura; Serra, Dolors; Casals i Farré, Núria (Molecular Metabolism, 2019-01)
      Objective: Carnitine palmitoyltransferase 1C (CPT1C) is implicated in central regulation of energy homeostasis. Our aim was to investigate whether CPT1C in the ventromedial nucleus of the hypothalamus ...

    • CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity 

      Sierra, Adriana Y.; Gratacòs-Batlle, Esther; Carrasco, Patricia; Clotet Erra, Josep; Ureña, Jesús; Serra, Dolors; Asins, Guillermina; Hegardt, Fausto G.; Casals i Farré, Núria (Journal of Biological Chemistry, 2008)
      CPT1c is a carnitine palmitoyltransferase 1 (CPT1) isoform that is expressed only in the brain. The enzyme has recently been localized in neuron mitochondria. Although it has high sequence identity with ...

    • CPT1C is required for synaptic plasticity and oscillatory activity that supports motor, associative and non-associative learning 

      Iborra-Lázaro, Guillermo; Djebari, Souhail; Sánchez-Rodríguez, Irene; Gratacòs-Batlle, Esther; Sánchez-Fernández, Nuria; Radošević, Marija; Casals, Núria; Navarro-López, Juan de Dios; Soto del Cerro, David; Jiménez-Díaz, Lydia (The Journal of Physiology, 2023)
      Carnitine palmitoyltransferase 1c (CPT1C) is a neuron-specific protein widely distributed throughout the CNS and highly expressed in discrete brain areas including the hypothalamus, hippocampus, amygdala ...

    • CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy 

      Roa Mansergas, Xavier; Fadó Andrés, Rut; Atari Abouassi, Maher; Mir, Joan Francesc; Muley Vilamú, Helena; Serra, Dolors; Casals i Farré, Núria (Scientific Reports, 2018-05-03)
      Human mesenchymal stem cells (hMSCs) are widely used in regenerative medicine. In some applications, they must survive under low nutrient conditions engendered by avascularity. Strategies to improve ...

    • Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders 

      Mingorance, Carmen; Rodríguez-Rodríguez, Rosalía; Justo, María Luisa; Álvarez de Sotomayor, María; Dolores Herrera, María (Vascular Health and Risk Management, 2011-03-28)
      Acetyl-L-carnitine (ALC) and propionyl-L-carnitine (PLC) are two naturally occurring carnitine derivates formed by carnitine acetyltransferase. The beneficial cardiovascular effects of ALC and PLC have ...

    • ¿Cuál es su diagnóstico? 

      Sambo Salas, Paola Cristina; Lasa Menéndez, Víctor; Prieto Gundin, Alejandra; Suñol, Mariona; Rubio-Palau, Josep (Revista Española de Cirugía Oral y Maxilofacial, 2019)
      Se presenta el caso de un niño de 11 años de edad, sin antecedentes patológicos de interés y correctamente vacunado, que acude por presentar una tumoración mandibular dolorosa de 1 mes de evolución. Se ...

    • Current and future perspectives in lung cancer prevention 

      González-Marrón, Adrián; Martín-Sánchez, Juan Carlos; Martínez-Sánchez, Jose M. (Precision Cancer Medicine, 2020)
      Smoking is one of the leading causes of morbidity and mortality worldwide. Tobacco smoke contains thousands of different heterogeneous substances, dozens of them classified as carcinogenic for humans, ...

    • Current and future perspectives in lung cancer prevention 

      González-Marrón, Adrián; Martín-Sánchez, Juan Carlos; Martínez-Sánchez, Jose M. (Precision Cancer Medicine: a Journal Aiming to Deliver a Lasting Blow to Cancer, 2020)
      Smoking is one of the leading causes of morbidity and mortality worldwide. Tobacco smoke contains thousands of different heterogeneous substances, dozens of them classified as carcinogenic for humans, ...

    • Current challenges for targeting brown fat thermogenesis to combat obesity 

      Yoneshiro, Takeshi; Rodríguez-Rodríguez, Rosalía; Johannes Betz, Matthias; Rensen, Patrick C. N. (Frontiers in Endocrinology, 2020-10-27)
      Just over a decade has passed since metabolically active brown adipose tissue (BAT) was unequivocally identified in healthy adult humans. Since then, researchers have provided evidence of expression of ...

    • Current controversies in trichology: a European expert consensus statement 

      Meyer-Gonzalez, T.; Bacqueville, D.; Grimalt Santacana, Ramon; Mengeaud, V.; Piraccini, Bianca Maria; Rudnicka, L.; Saceda-Corralo, D.; Vogt, A.; Trichology Experts Network Group; Vano-Galvan, S. (Journal of the European Academy of Dermatology and Venereology, 2021)
      Introduction: Hair disorders are one of the most common conditions within dermatology practice but, although new diagnostic tools and therapeutic options have arisen, the management of these patients ...

    • Cystic fibrosis in Brazil: achievements in survival 

      Vendrusculo, Fernanda Maria; Fagundes Donadio, Márcio Vinícius; Araújo Pinto, Leonardo (Jornal Brasileiro de Pneumologia, 2021)

    • Daptomycin plus fosfomycin versus daptomycin alone for methicillin-resistant staphylococcus aureus bacteremia and endocarditis: a randomized clinical trial 

      Pujol, Miquel; Miró, José-María; Shaw, Evelyn; Aguado, Jose-María; San-Juan, Rafael; Puig-Asensio, Mireia; Pigrau, Carles; Calbo Sebastián, Esther; Montejo, Miguel; Rodriguez-Álvarez, Regino; Garcia-Pais, María-Jose; Pintado, Vicente; Escudero-Sánchez, Rosa; Lopez-Contreras, Joaquín (Clinical Infectious Diseases, 2021)
      Background: We aimed to determine whether daptomycin plus fosfomycin provides higher treatment success than daptomycin alone for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and ...

    • Daptomycin plus fosfomycin versus daptomycin alone for methicillin-resistant staphylococcus aureus bacteremia and endocarditis: a randomized clinical trial 

      Pujol, Miquel; Miró, José-María; Shaw, Evelyn; Aguado, Jose-María; San-Juan, Rafael; Puig-Asensio, Mireia; Pigrau, Carles; Calbo Sebastián, Esther; Montejo, Miguel; Rodriguez-Álvarez, Regino; Garcia-Pais, María-Jose; Pintado, Vicente; Escudero-Sánchez, Rosa; Lopez-Contreras, Joaquín; Morata, Laura; Montero, Milagros; Andrés, Marta; Pasquau, Juan; Arenas, María-del-Mar; Padilla, Belén; Murillas, Javier; Jover-Sáenz, Alfredo; López-Cortes, Luis-Eduardo; García-Pardo, Graciano; Gasch, Oriol; Videla, Sebastian; Hereu, Pilar; Tebé, Cristian; Pallarès, Natalia; Sanllorente, Mireia; Domínguez, María-Ángeles; Càmara, Jordi; Ferrer, Anna; Padullés, Ariadna; Cuervo, Guillermo; Carratalà, Jordi; MRSA Bacteremia (BACSARM) Trial Investigators (Clinical Infectious Diseases, 2020)
      Background: We aimed to determine whether daptomycin plus fosfomycin provides higher treatment success than daptomycin alone for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and ...

    • Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1 

      Hernández, Gonzalo; Ramírez, María José; Minguillón, Jordi; Quiles, Paco; Ruiz de Garibay, Gorka; Aza-Carmona, Miriam; Bogliolo, Massimo; Pujol, Roser; Prados-Carvajal, Rosario; Fernández, Juana; García, Nadia; López, Adrià; Gutiérrez-Enríquez, Sara; Diez, Orland; Benítez, Javier; Salinas, Mónica; Teulé, Alex; Brunet, Joan; Radice, Paolo; Peterlongo, Paolo; Schindler, Detlev; Huertas, Pablo; Puente, Xose S.; Lázaro, Conxi; Pujana, Miquel Àngel; Surrallés, Jordi (Nature Communications, 2018)
      BRCA1 is a tumor suppressor that regulates DNA repair by homologous recombination. Germline mutations in BRCA1 are associated with increased risk of breast and ovarian cancer and BRCA1 deficient tumors ...

    • Defective in mitotic arrest 1 (Dma1) ubiquitin ligase controls G1 cyclin degradation 

      Hernández-Ortega, Sara; Bru Rullo, Samuel; Ricco Pacheco, Natalia; Ramírez, Sara; Casals i Farré, Núria; Jiménez, Javier; Isasa, Marta; Crosas, Bernat; Clotet Erra, Josep (Journal of Biological Chemistry, 2013-02)
      Progression through the G1 phase of the cell cycle is controlled by diverse cyclin-dependent kinases (CDKs) that might be associated to numerous cyclin isoforms. Given such complexity, regulation of ...

    • Definition and validation of the nursing diagnosis label “wish to die”: a research protocol 

      Monforte-Royo, Cristina; Goni-Fuste, Blanca; Crespo, Iris; Pergolizzi, Denise; Martin Delgado, Leandra; Fuster, Pilar; Bellido Perez, Mercedes; Tomás Sábado, Joaquín; Rodríguez Prat, Andrea (BMC Nursing, 2024)
      Background: Euthanasia has been incorporated into the health services of seven countries. The legalisation of these practices has important repercussions for the competences of nurses, and it raises ...

    • Deformations and ruptures in human lenses with cortical cataract subjected to ex vivo simulated accommodation 

      Michael, Ralph; D'Antin, Justin Christopher; Pinilla Cortés, Laura; Burd, Harvey John; Sheil, Brian; Barraquer, Rafael I. (Investigative Ophthalmology & Visual Science, 2021)
      Purpose: Human cortical opacities are most commonly accompanied by changes in lens fiber structure in the equatorial region at the lens nucleus–cortex interface. Cortex and nucleus have different elastic ...

    • Delayed cerebral vasculopathy in pneumococcal meningitis: epidemiology and clinical outcome. A cohort study 

      Boix-Palop, Lucía; Fernández, Tamara; Pelegrín, Iván; Obradors, Meritxell; García-Roulston, Kevin; Xercavins Valls, Mariona; García-Somoza, Dolors; Ardanuy, Carmen; Grau, Javier; Calbo Sebastián, Esther; Cabellos, Carmen (International Journal of Infectious Diseases, 2020-08)
      Background: To describe the prevalence, clinical characteristics, impact of systemic steroids exposure and outcomes of delayed cerebral vasculopathy (DCV) in a cohort of adult patients with pneumococcal ...