Now showing items 148-167 of 710

    • COVID-19 after two years: trajectories of different components of mental health in the Spanish population 

      Bayes-Marin, Ivet; Cabello-Toscano, M; Cattaneo, G; Solana-Sánchez, J; Fernández, D; Portellano-Ortiz, C; Tormos, J M; Pascual-Leone, A; Bartrés-Faz, D (Epidemiology and psychiatric sciences, 2023)
      Our study aimed to (1) identify trajectories on different mental health components during a two-year follow-up of the COVID-19 pandemic and contextualise them according to pandemic periods; (2) investigate ...
    • COVID-19 lockdown: impact on oral health-related behaviors and practices of portuguese and spanish children 

      Costa, Ana Luísa; Pereira, Joana Leonor; Franco, Lara; Guinot Jimeno, Francisco (International Journal of Environmental Reseacrh and Public Health, 2022)
      This study aimed to assess and compare the impact of COVID-19 pandemic lockdowns on the oral health attitudes, dietary habits and access to dental care of Portuguese and Spanish children. A cross-sectional ...
    • COVID-19 pandemic psychological impact and volunteering experience perceptions of medical students after 2 years 

      Gómez Durán, Esperanza Luisa; Martin-Fumadó, Carles; Gassó, Aina M.; Díaz, Sandra; Miranda-Mendizabal, Andrea; Garcia Forero, Carlos; Virumbrales, Montserrat (International Journal of Environmental Research and Public Health, 2022)
      Undergraduate healthcare students were mobilized to support healthcare systems during the COVID-19 pandemic, but we have scarce information regarding their experience and its impact on their wellbeing. ...
    • Covid-19, an opportunity to compare in-person and online teaching 

      Bru, Samuel; Ribeiro, Mariana PC; Quandt, Eva; Clotet, Josep; Jiménez Jiménez, Javier (Revista Española de Educación Médica, 2021)
      For years it has been discussed the dichotomy between traditional in-person teaching versus online instruction. The lockdown, consequence of the Covid-19 pandemic, gave us an opportunity to gain evidence ...
    • COVID-19: making the best out of a forced transition to online medical teaching. A mixed methods study 

      Virumbrales Cancio, Montserrat; Elorduy, Marta; Graell, Mariona; Mezquita, Pau; Brotons de Los Reyes, Pedro; Balaguer Santamaría, Albert (Medical Science Educator, 2021)
      Introduction the COVID-19 pandemic resulted in a decreed confinement in our country from March until the end of term in June 2020. This forced a transition exclusively to distance learning. The aim of ...
    • CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst 

      Zagmutt, Sebastián; Mera, Paula; González García, Ismael; Ibeas, Kevin; Romero, María del Mar; Obri, Arnaud; Martin, Beatriz; Esteve Codina, Anna; Soler Vázquez, M. Carmen; Bastias Pérez, Marianela; Cañes, Laia; Augé, Elisabeth; Pelegri, Carme; Vilaplana, Jordi; Ariza, Xavier; García, Jordi; Martinez González, José; Casals, Núria; López, Miguel; Palmiter, Richard; Sanz, Elisenda; Quintana, Albert; Herrero, Laura; Serra, Dolors (Biology of Sex Differences, 2023)
      Background: Fatty acid metabolism in the hypothalamus has an important role in food intake, but its specific role in AgRP neurons is poorly understood. Here, we examined whether carnitinea palmitoyltransferase ...
    • Cpt1c downregulation causes plasma membrane remodelling and anthracycline resistance in breast cancer 

      Muley, Helena; Valencia, Karmele; Casas, Josefina; Moreno, Bea; Botella, Luis; Lecanda, Fernando; Fadó, Rut; Casals, Núria (International Journal of Molecular Sciences, 2023)
      Breast cancer (BC) is the most common malignancy in women worldwide. While the main systemic treatment option is anthracycline-containing chemotherapy, chemoresistance continues to be an obstacle to ...
    • CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity 

      Rodríguez-Rodríguez, Rosalía; Miralpeix Monclús, Cristina; Fosch, Anna; Pozo Ariza, Macarena; Calderón-Domínguez, María; Perpinyà, Xavier; Vellvehí, Miquel; López, Miguel; Herrero Rodríguez, Laura; Serra, Dolors; Casals i Farré, Núria (Molecular Metabolism, 2019-01)
      Objective: Carnitine palmitoyltransferase 1C (CPT1C) is implicated in central regulation of energy homeostasis. Our aim was to investigate whether CPT1C in the ventromedial nucleus of the hypothalamus ...
    • CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity 

      Sierra, Adriana Y.; Gratacòs-Batlle, Esther; Carrasco, Patricia; Clotet Erra, Josep; Ureña, Jesús; Serra, Dolors; Asins, Guillermina; Hegardt, Fausto G.; Casals i Farré, Núria (Journal of Biological Chemistry, 2008)
      CPT1c is a carnitine palmitoyltransferase 1 (CPT1) isoform that is expressed only in the brain. The enzyme has recently been localized in neuron mitochondria. Although it has high sequence identity with ...
    • CPT1C is required for synaptic plasticity and oscillatory activity that supports motor, associative and non-associative learning 

      Iborra-Lázaro, Guillermo; Djebari, Souhail; Sánchez-Rodríguez, Irene; Gratacòs-Batlle, Esther; Sánchez-Fernández, Nuria; Radošević, Marija; Casals, Núria; Navarro-López, Juan de Dios; Soto del Cerro, David; Jiménez-Díaz, Lydia (The Journal of Physiology, 2023)
      Carnitine palmitoyltransferase 1c (CPT1C) is a neuron-specific protein widely distributed throughout the CNS and highly expressed in discrete brain areas including the hypothalamus, hippocampus, amygdala ...
    • CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy 

      Roa Mansergas, Xavier; Fadó Andrés, Rut; Atari Abouassi, Maher; Mir, Joan Francesc; Muley Vilamú, Helena; Serra, Dolors; Casals i Farré, Núria (Scientific Reports, 2018-05-03)
      Human mesenchymal stem cells (hMSCs) are widely used in regenerative medicine. In some applications, they must survive under low nutrient conditions engendered by avascularity. Strategies to improve ...
    • Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders 

      Mingorance, Carmen; Rodríguez-Rodríguez, Rosalía; Justo, María Luisa; Álvarez de Sotomayor, María; Dolores Herrera, María (Vascular Health and Risk Management, 2011-03-28)
      Acetyl-L-carnitine (ALC) and propionyl-L-carnitine (PLC) are two naturally occurring carnitine derivates formed by carnitine acetyltransferase. The beneficial cardiovascular effects of ALC and PLC have ...
    • ¿Cuál es su diagnóstico? 

      Sambo Salas, Paola Cristina; Lasa Menéndez, Víctor; Prieto Gundin, Alejandra; Suñol, Mariona; Rubio-Palau, Josep (Revista Española de Cirugía Oral y Maxilofacial, 2019)
      Se presenta el caso de un niño de 11 años de edad, sin antecedentes patológicos de interés y correctamente vacunado, que acude por presentar una tumoración mandibular dolorosa de 1 mes de evolución. Se ...
    • Current and future perspectives in lung cancer prevention 

      González-Marrón, Adrián; Martín-Sánchez, Juan Carlos; Martínez-Sánchez, Jose M. (Precision Cancer Medicine, 2020)
      Smoking is one of the leading causes of morbidity and mortality worldwide. Tobacco smoke contains thousands of different heterogeneous substances, dozens of them classified as carcinogenic for humans, ...
    • Current and future perspectives in lung cancer prevention 

      González-Marrón, Adrián; Martín-Sánchez, Juan Carlos; Martínez-Sánchez, Jose M. (Precision Cancer Medicine: a Journal Aiming to Deliver a Lasting Blow to Cancer, 2020)
      Smoking is one of the leading causes of morbidity and mortality worldwide. Tobacco smoke contains thousands of different heterogeneous substances, dozens of them classified as carcinogenic for humans, ...
    • Current challenges for targeting brown fat thermogenesis to combat obesity 

      Yoneshiro, Takeshi; Rodríguez-Rodríguez, Rosalía; Johannes Betz, Matthias; Rensen, Patrick C. N. (Frontiers in Endocrinology, 2020-10-27)
      Just over a decade has passed since metabolically active brown adipose tissue (BAT) was unequivocally identified in healthy adult humans. Since then, researchers have provided evidence of expression of ...
    • Current controversies in trichology: a European expert consensus statement 

      Meyer-Gonzalez, T.; Bacqueville, D.; Grimalt Santacana, Ramon; Mengeaud, V.; Piraccini, Bianca Maria; Rudnicka, L.; Saceda-Corralo, D.; Vogt, A.; Trichology Experts Network Group; Vano-Galvan, S. (Journal of the European Academy of Dermatology and Venereology, 2021)
      Introduction: Hair disorders are one of the most common conditions within dermatology practice but, although new diagnostic tools and therapeutic options have arisen, the management of these patients ...
    • Cystic fibrosis in Brazil: achievements in survival 

      Vendrusculo, Fernanda Maria; Fagundes Donadio, Márcio Vinícius; Araújo Pinto, Leonardo (Jornal Brasileiro de Pneumologia, 2021)
    • Daptomycin plus fosfomycin versus daptomycin alone for methicillin-resistant staphylococcus aureus bacteremia and endocarditis: a randomized clinical trial 

      Pujol, Miquel; Miró, José-María; Shaw, Evelyn; Aguado, Jose-María; San-Juan, Rafael; Puig-Asensio, Mireia; Pigrau, Carles; Calbo Sebastián, Esther; Montejo, Miguel; Rodriguez-Álvarez, Regino; Garcia-Pais, María-Jose; Pintado, Vicente; Escudero-Sánchez, Rosa; Lopez-Contreras, Joaquín (Clinical Infectious Diseases, 2021)
      Background: We aimed to determine whether daptomycin plus fosfomycin provides higher treatment success than daptomycin alone for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and ...
    • Daptomycin plus fosfomycin versus daptomycin alone for methicillin-resistant staphylococcus aureus bacteremia and endocarditis: a randomized clinical trial 

      Pujol, Miquel; Miró, José-María; Shaw, Evelyn; Aguado, Jose-María; San-Juan, Rafael; Puig-Asensio, Mireia; Pigrau, Carles; Calbo Sebastián, Esther; Montejo, Miguel; Rodriguez-Álvarez, Regino; Garcia-Pais, María-Jose; Pintado, Vicente; Escudero-Sánchez, Rosa; Lopez-Contreras, Joaquín; Morata, Laura; Montero, Milagros; Andrés, Marta; Pasquau, Juan; Arenas, María-del-Mar; Padilla, Belén; Murillas, Javier; Jover-Sáenz, Alfredo; López-Cortes, Luis-Eduardo; García-Pardo, Graciano; Gasch, Oriol; Videla, Sebastian; Hereu, Pilar; Tebé, Cristian; Pallarès, Natalia; Sanllorente, Mireia; Domínguez, María-Ángeles; Càmara, Jordi; Ferrer, Anna; Padullés, Ariadna; Cuervo, Guillermo; Carratalà, Jordi; MRSA Bacteremia (BACSARM) Trial Investigators (Clinical Infectious Diseases, 2020)
      Background: We aimed to determine whether daptomycin plus fosfomycin provides higher treatment success than daptomycin alone for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and ...