Browsing Ciències de la Salut by Title
Now showing items 398-417 of 730
-
Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype
(Nature Metabolism, 2023)Fibrogenesis is part of a normal protective response to tissue injury that can become irreversible and progressive, leading to fatal diseases. Senescent cells are a main driver of fibrotic diseases ... -
Iron refractory iron deficiency anemia
(Haematologica, 2013)Iron refractory iron deficiency anemia is a hereditary recessive anemia due to a defect in the TMPRSS6In vitro gene encoding Matriptase-2. This protein is a transmembrane serine protease that plays an ... -
Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins
(Blood, 2011)Iron regulatory proteins (IRPs) 1 and 2 are RNA-binding proteins that control cellular iron metabolism by binding to conserved RNA motifs called iron-responsive elements (IREs). The currently known ... -
Iron-regulatory proteins limit hypoxia-inducible factor 2α expression in iron deficiency
(Nature Structural & Molecular Biology, 2007)Hypoxia stimulates erythropoiesis, the major iron-utilization pathway. We report the discovery of a conserved, functional iron-responsive element (IRE) in the 5′ untranslated region of the messenger RNA ... -
The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays
(BMC Bioinformatics, 2010)Background: Gene expression studies greatly contribute to our understanding of complex relationships in gene regulatory networks. However, the complexity of array design, production and manipulations ... -
Is dry needling of the supinator a safe procedure? A potential treatment for lateral epicondylalgia or radial tunnel syndrome. A cadaveric study
(International Journal of Environmental Research and Public Health, 2021)The supinator muscle is involved in two pain conditions of the forearm and wrist: lateral epicondylalgia and radial tunnel syndrome. Its close anatomical relationship with the radial nerve at the arcade ... -
Isolated acute hemorrhagic edema of the eyelids
(Journal of Respiratory Research, 2019-12)Perivascular epithelioid cell tumors (PEComas) are rare tumors which can arise in almost every body site. Little is still known about these tumors because of the limited number of cases described by far ... -
K-means clustering identifies diverse clinical phenotypes in COVID-19 patients: implications for mortality risks and remdesivir impact
(12, 2024)Introduction: The impact of remdesivir on mortality in patients with COVID-19 is still controversial. We aimed to identify clinical phenotype clusters of COVID-19 hospitalized patients with highest ... -
Kinematic analysis of human gait in healthy young adults using IMU sensors: exploring relevant machine learning features for clinical applications
(Bioengineering, 2024)Background: Gait is the manner or style of walking, involving motor control and coordination to adapt to the surrounding environment. Knowing the kinesthetic markers of normal gait is essential for the ... -
Knowledge and opinions of healthcare professionals about thirdhand smoke: a multi-national, cross-sectional study
(Healthcare, 2022)There is scarce evidence on the knowledge and opinions about third-hand smoke (THS) of health care professionals. The main aim of this study was to explore the knowledge and opinions of health care ... -
Knowledge management for systems biology a general and visually driven framework applied to translational medicine
(BMC Systems Biology, 2011)Background: To enhance our understanding of complex biological systems like diseases we need to put all of the available data into context and use this to detect relations, pattern and rules which allow ... -
L-ferritin: one gene, five diseases; from hereditary hyperferritinemia to hypoferritinemia - report of new cases
(Pharmaceuticals, 2019)Ferritin is a multimeric protein composed of light (L-ferritin) and heavy (H-ferritin) subunits that binds and stores iron inside the cell. A variety of mutations have been reported in the L-ferritin ... -
Latent class analysis of multimorbidity patterns and associated outcomes in Spanish older adults: a prospective cohort study
(BioMed Central geriatrics, 2017)This study sought to identify multimorbidity patterns and determine the association between these latent classes with several outcomes, including health, functioning, disability, quality of life and use ... -
Limited joint mobility progression in type 1 diabetes: a 15-year follow-up study
(International Journal of Endocrinology, 2018)Objective. To assess the evolution of joint mobility over a period of 15 years in type 1 diabetic patients and healthy controls and to determine whether microalbuminuria is associated with a different ... -
Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD
(Federation of American Societies for Experimental Biology, 2020)The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased drastically due to the global obesity pandemic but at present there are no approved therapies. Here, we aimed to revert high‐fat ... -
Localized refractive changes induced by symmetric and progressive asymmetric intracorneal ring segments assessed with a 3D finite-element model
(Bioengineering, 2023)To build a representative 3D finite element model (FEM) for intracorneal ring segment (ICRS) implantation and to investigate localized optical changes induced by different ICRS geometries, a hyperelastic ... -
Long-term anatomical and functional outcomes after autokeratoplasty
(British Journal of Ophthalmology, 2021)Background: To evaluate the anatomical and functional outcomes of autologous contralateral penetrating keratoplasty (autokeratoplasty). Methods: Kaplan-Meier survival analyses were retrospectively ... -
Long-term anatomical and functional survival of Boston type 1 keratoprosthesis in congenital aniridia
(Frontiers in Medicine, 2021)Purpose: To analyze the long-term anatomical survival, functional survival, and complications of Boston type 1 keratoprosthesis (KPro) in the eyes with congenital aniridia-associated keratopathy (AAK). ... -
Long-term efficacy and effectiveness of abehavioural and community-basedexercise intervention (Urban Training) toincrease physical activity in patients withCOPD: a randomised controlled trial
(European Respiratory Journal, 2018)There is a need to increase and maintain physical activity in patients with chronic obstructive pulmonary disease (COPD). We assessed 12-month efficacy and effectiveness of the Urban Training intervention ...