CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy
Visualitza/Obre
Autor/a
Roa Mansergas, Xavier
Fadó Andrés, Rut
Atari Abouassi, Maher
Mir, Joan Francesc
Muley Vilamú, Helena
Serra, Dolors
Casals i Farré, Núria
Data de publicació
2018-05-03ISSN
2045-2322
Resum
Human mesenchymal stem cells (hMSCs) are widely used in regenerative medicine. In some
applications, they must survive under low nutrient conditions engendered by avascularity. Strategies to
improve hMSCs survival may be of high relevance in tissue engineering. Carnitine palmitoyltransferase
1 C (CPT1C) is a pseudoenzyme exclusively expressed in neurons and cancer cells. In the present
study, we show that CPT1C is also expressed in hMSCs and protects them against glucose starvation,
glycolysis inhibition, and oxygen/glucose deprivation. CPT1C overexpression in hMSCs did not increase
fatty acid oxidation capacity, indicating that the role of CPT1C in these cells is different from that
described in tumor cells. The increased survival of CPT1C-overexpressing hMSCs observed during
glucose deficiency was found to be the result of autophagy enhancement, leading to a greater number
of lipid droplets and increased intracellular ATP levels. In fact, inhibition of autophagy or lipolysis was
observed to completely block the protective effects of CPT1C. Our results indicate that CPT1C-mediated
autophagy enhancement in glucose deprivation conditions allows a greater availability of lipids to be
used as fuel substrate for ATP generation, revealing a new role of CPT1C in stem cell adaptation to low
nutrient environments.
Tipus de document
Article
Versió del document
Versió acceptada
Llengua
English
Matèries (CDU)
61 - Medicina
Paraules clau
Cèl·lules mare
Stem cells
Células madre
Medicina regenerativa
Regenerative medicine
CPT1C
Pàgines
13
Publicat per
Nature Research
Col·lecció
8;
Publicat a
Scientific Reports
Citació
Roa-Mansergas, Xavier; Fadó Andrés, Rut; Atari Abouassi, Maher; Mir, Joan F.; Muley, Helena; Serra, Dolors; Casals i Farré, Núria. «CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy». Scientific Reports, 2018, vol. 8, art. 6997. Disponible en: <https://www.nature.com/articles/s41598-018-25485-7>. Fecha de acceso: 16 oct. 2019. DOI: 10.1038/s41598-018-25485-7
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