The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration
Autor/a
Sánchez Botet, Abril
Gasa Colom, Laura
Jiménez Jiménez, Javier
Mezquita Mas, Pau
Carrasco García, Miguel Ángel
Kron, Stephen J.
Villanueva, Alberto
P.C. Ribeiro, Mariana
Clotet Erra, Josep
Fecha de publicación
2018-08-07DOI
10.1038/s41598-018-30307-x
ISSN
2045-2322
Resumen
Colorectal cancer (CRC) is one of the most common cancers worldwide, with 8–10% of these tumours presenting a BRAF (V600E) mutation. Cyclins are known oncogenes deregulated in many cancers, but the role of the new subfamily of atypical cyclins remains elusive. Here we have performed a systematic analysis of the protein expression levels of eight atypical cyclins in human CRC tumours and several cell lines, and found that CNTD2 is significantly upregulated in CRC tissue compared to the adjacent normal one. CNTD2 overexpression in CRC cell lines increases their proliferation capacity and migration, as well as spheroid formation capacity and anchorage-independent growth. Moreover, CNTD2 increases tumour growth in vivo on xenograft models of CRC with wild-type BRAF. Accordingly, CNTD2 downregulation significantly diminished the proliferation of wild-type BRAF CRC cells, suggesting that CNTD2 may represent a new prognostic factor and a promising drug target in the management of CRC.
Tipo de documento
Artículo
Versión del documento
Versión aceptada
Lengua
English
Materias (CDU)
616.3 - Patología del aparato digestivo. Odontología
Palabras clave
colon cancer
cáncer de colon
càncer de colon
CNTD2
tumours
tumores
tumors
Páginas
12
Publicado por
Scientific Reports
Citación
Sánchez-Botet, A., Gasa, L., Quandt, E., Hernández-Ortega, S., Jiménez, J., Mezquita, P., Carrasco García, M.A., J. Kron, Stephen, Vidal, August, Villanueva, Alberto, Ribeiro, M. P. & Clotet, Josep (2018). «The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration». Scientific reports, 8(1), 11797.
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https://creativecommons.org/licenses/by/4.0/
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