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Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balance
(John Wiley & Sons, 2023)
Tackling the growing incidence and prevalence of obesity urgently requires uncovering new molecular pathways with therapeutic potential. The brain, and in particular the hypothalamus, is a major integrator ...
Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice
(Elsevier, 2023-05)
Obesity and its associated metabolic comorbidities are a rising global health and social issue, with novel therapeutic approaches urgently needed. Adipose tissue plays a key role in the regulation of ...
Central regulation of brown fat thermogenesis in response to saturated or unsaturated long-chain fatty acids
(MDPI, 2023)
Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance, and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on hypothalamic-brown ...