Search
Now showing items 1-5 of 5
The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays
(Springer Nature, 2010)
Background: Gene expression studies greatly contribute to our understanding of complex relationships in gene regulatory networks. However, the complexity of array design, production and manipulations ...
Simulation methods with extended stability for stiff biochemical Kinetics
(Springer Nature, 2010)
Background: With increasing computer power, simulating the dynamics of complex systems in chemistry and biology is becoming increasingly routine. The modelling of individual reactions in (bio)chemical ...
SIREs: searching for iron-responsive elements
(Oxford University Press, 2010-07)
The iron regulatory protein/iron-responsive element regulatory system plays a crucial role in the post-transcriptional regulation of gene expression and its disruption results in human disease. IREs are ...
Single-molecule derivation of salt dependent base-pair free energies in DNA
(National Academy of Sciences, 2010)
Accurate knowledge of the thermodynamic properties of nucleic acids is crucial to predicting their structure and stability. To date most measurements of base-pair free energies in DNA are obtained in ...
Investigating the thermodynamics of small biosystems with optical tweezers
(Elsevier, 2010)
We present two examples of how single-molecule experimental techniques applied to biological systems can give insight into problems within the scope of equilibrium and nonequilibrium mesoscopic ...