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Emergency short-stay unit as an effective alternative to in-hospital admission for acute exacerbation of chronic heart failure
(Scientific Research Publishing, 2014-10)
Study Objective: To determine whether a new emergency department short-stay unit (EDSSU) was an effective alternative to conventional hospital units (HU) for acute exacerbation of chronic heart failure ...
EQUIPT: protocol of a comparative effectiveness research study evaluating cross-context transferability of economic evidence on tobacco control
(BMJ Publishing Group, 2014-11-24)
Introduction: Tobacco smoking claims 700 000 lives
every year in Europe and the cost of tobacco smoking in
the EU is estimated between €98 and €130 billion
annually; direct medical care costs and ...
Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation
(Public Library of Science, 2014-06-06)
In response to peripheral nerve injury, Schwann cells adopt a migratory phenotype and modify the extracellular matrix to make it permissive for cell migration and axonal re-growth. Uridine 5′-triphosphate ...
Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance
(Elsevier, 2014-10)
Hypothalamic endoplasmic reticulum (ER) stress is a key mechanism leading to obesity. Here, we demonstrate that ceramides induce lipotoxicity and hypothalamic ER stress, leading to sympathetic inhibition, ...
Economic impact of HIV/AIDS: a systematic review in five European countries
(SpringerOpen, 2014-09-16)
The HIV/AIDS disease represent a priority for all health authorities in all countries and it also represents serious added socioeconomic problems for societies over the world. The aim of this paper is ...
Distinct structural transitions of chromatin topological domains correlate with coordinated hormone-induced gene regulation
(Cold Spring Harbor Laboratory Press, 2014)
The human genome is segmented into topologically associating domains (TADs), but the role of this conserved organization during transient changes in gene expression is not known. Here we describe the ...
Molecular evolution of multiple-level control of heme biosynthesis pathway in animal kingdom
(Public Library of Science, 2014)
Adaptation of enzymes in a metabolic pathway can occur not only through changes in amino acid sequences but also through variations in transcriptional activation, mRNA splicing and mRNA translation. The ...
Short-term effect of antibiotics on human gut microbiota
(Public Library of Science, 2014-04-18)
From birth onwards, the human gut microbiota rapidly increases in diversity and reaches an adult-like stage at three years of age. After this age, the composition may fluctuate in response to external ...
Analysis of three strategies to increase screening coverage for cervical cancer in the general population of women aged 60 to 70 years: the CRICERVA study
(BMC, 2014-07-16)
Background: Cervical cancer is a frequently diagnosed cancer in women worldwide. Despite having easy
preventive and therapeutic approaches, it is an important cause of mortality among women.
Methods: ...
A barbed suture repair for flexor tendons: a novel technique with no exposed barbs
(Lippincott, Williams & Wilkins, 2014-10-23)
Background: Barbed suture technology has shown promise in flexor tendon
repairs, as there is an even distribution of load and the need for a knot
is eliminated. We propose that a quick and simple, ...