• Association between kidney function, nutritional status and anthropometric measures in older people: the screening for CKD among older people across Europe (SCOPE) study 

      Guligowska, Agnieszka; Corsonello, Andrea; Pigłowska, Małgorzata; Roller-Wirnsberger, Regina; Wirnsberger, Gerhard; Ärnlöv, Johan; Carlsson, Axel C.; Tap, Lisanne; Mattace-Raso, Francesco; Formiga, Francesc; Moreno-Gónzalez, Rafael; Freiberger, Ellen; Sieber, Cornel; Gregorio, Pedro Gil; Laínez Martínez, Sara; Artzi-Medvedik, Rada; Yehoshua, Ilan; Fabbietti, Paolo; Lattanzio, Fabrizia; Kostka, Tomasz; SCOPE investigators; Corbella Virós, Xavier (BMC Geriatrics, 2020-10-02)
      Background: Different mechanisms connect the nutritional status with the occurrence and the course of chronic kidney disease (CKD). The end-stage renal disease is complicated by catabolic inflammatory ...
    • Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance 

      Contreras, Cristina; González-García, Ismael; Martínez-Sánchez, Noelia; Seoane-Collazo, Patricia; Jacas i Mateu, Jordi; Morgan, Donald A.; Serra, Dolors; Gallego, Rosalía; Gonzalez, Francisco; Casals i Farré, Núria; Nogueiras, Rubén; Rahmouni, Kamal; Diéguez, Carlos; López, Miguel (Cell Reports, 2014-10)
      Hypothalamic endoplasmic reticulum (ER) stress is a key mechanism leading to obesity. Here, we demonstrate that ceramides induce lipotoxicity and hypothalamic ER stress, leading to sympathetic inhibition, ...
    • Central regulation of brown fat thermogenesis in response to saturated or unsaturated long-chain fatty acids 

      Fosch Masllovet, Anna; Rodríguez García, Maria; Miralpeix , Cristina; Zagmutt, Sebastián; Larrañaga Fernandez, Maite; Reguera, Ana Cristina; Garcia-Chica, Jesus; Herrero, Laura; Serra, Dolors; Casals, Nuria; Rodriguez-Rodriguez, Rosalia (International Journal of Molecular Sciences, 2023)
      Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance, and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on hypothalamic-brown ...
    • CPT1C and endocannabinoids as hypothalamic players in early stages of obesity development 

      Miralpeix Monclús, Cristina (Fecha de defensa: 2019-12-10)
      Obesity prevalence in worldwide population is increasing every day due to an imbalance between the energy intake and the energy expenditure. Rich-caloric food is highly palatable and easily accessible, ...
    • CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity 

      Rodríguez-Rodríguez, Rosalía; Miralpeix Monclús, Cristina; Fosch, Anna; Pozo Ariza, Macarena; Calderón-Domínguez, María; Perpinyà, Xavier; Vellvehí, Miquel; López, Miguel; Herrero Rodríguez, Laura; Serra, Dolors; Casals i Farré, Núria (Molecular Metabolism, 2019-01)
      Objective: Carnitine palmitoyltransferase 1C (CPT1C) is implicated in central regulation of energy homeostasis. Our aim was to investigate whether CPT1C in the ventromedial nucleus of the hypothalamus ...
    • Current challenges for targeting brown fat thermogenesis to combat obesity 

      Yoneshiro, Takeshi; Rodríguez-Rodríguez, Rosalía; Johannes Betz, Matthias; Rensen, Patrick C. N. (Frontiers in Endocrinology, 2020-10-27)
      Just over a decade has passed since metabolically active brown adipose tissue (BAT) was unequivocally identified in healthy adult humans. Since then, researchers have provided evidence of expression of ...
    • Detección precoz de los factores de riesgo cardiovasculares en los centros de atención primaria de Cataluña central 

      Senent López, Rosa Mª (2014-06-26)
      Las enfermedades cardiovasculares son actualmente la principal causa de muerte prematura, por lo que es necesario controlar los factores que podrían reducir el riesgo cardiovascular. El presente estudio ...
    • Editorial: current challenges for targeting brown fat thermogenesis to combat obesity 

      Yoneshiro, Takeshi; Rodríguez-Rodríguez, Rosalía; Johannes Betz, Matthias; Rensen, Patrick C. N. (Frontiers in Endocrinology, 2020-10-27)
      Just over a decade has passed since metabolically active brown adipose tissue (BAT) was unequivocally identified in healthy adult humans. Since then, researchers have provided evidence of expression of ...
    • How do consumers respond to “sin taxes”? New evidence from a tax on sugary drinks 

      Fichera, Eleonora; Mora, Toni; G Lopez-Valcarcel, Beatriz; Roche, David (Social Science & Medicine, 2021-04)
      It is unclear what the effects of taxes on sugar sweetened beverages (SSBs) are on consumer behaviour and which consumers may be affected the most. We evaluate the effect of the SSB tax introduced in ...
    • Hypothalamic AMPK-ER Stress-JNK1 axis mediates the central actions of thyroid hormones on energy balance 

      Martinez-Sanchez, Noelia; Seoane-Collazo, Patricia; Contreras, Cristina; Varela, Luis; Villarroya, Joan; Rial-Pensado, Eva; Buque, Xabier; Aurrekoetxea, Igor; Delgado, Teresa C.; Vazquez-Martinez, Rafael; Gonzalez-Garcia, Ismael; Roa, Juan; Whittle, Andrew J.; Gomez-Santos, Beatriz; Velagapudi, Vidya; Loraine Tung, Y. C.; Morgan, Donald A.; Voshol, Peter J.; Martinez de Morentin, Pablo B.; Lopez-Gonzalez, Tania; Linares-Pose, Laura; Gonzalez, Francisco; Chatterjee, Krishna; Sobrino, Tomas; Medina-Gomez, Gema; Davis, Roger J.; Casals i Farré, Núria; Oresic, Matej; Coll, Anthony P.; Vidal-Puig, Antonio; Mittag, Jens; Tena-Sempere, Manuel; Malagon, Maria M.; Dieguez, Carlos; Martinez-Chantar, Maria Luz; Aspichueta, Patricia; Rahmouni, Kamal; Nogueiras, Rubén; Sabio, Guadalupe; Villarroya, Francesc; Lopez, Miguel (Cell Metabolism, 2017-07)
      Thyroid hormones (THs) act in the brain to modulate energy balance. We show that central triiodothyronine (T3) regulates de novo lipogenesis in liver and lipid oxidation in brown adipose tissue (BAT) ...
    • Hypothalamic endocannabinoids in obesity: an old story with new challenges 

      Miralpeix Monclús, Cristina; Reguera, Ana Cristina; Fosch, Anna; Zagmutt, Sebastián; Casals i Farré, Núria; Cota, Daniela; Rodríguez-Rodríguez, Rosalía (Cellular and Molecular Life Sciences, 2021)
      The crucial role of the hypothalamus in the pathogenesis of obesity is widely recognized, while the precise molecular and cellular mechanisms involved are the focus of intense research. A disrupted ...
    • Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice 

      Miralpeix Monclús, Cristina; Fosch, Anna; Casas, Josefina; Baena, Miguel; Herrero Rodríguez, Laura; Serra, Dolors; Rodríguez-Rodríguez, Rosalía; Casals i Farré, Núria (Journal of Lipid Research, 2019-07)
      The endocannabinoid (eCB) system regulates energy homeostasis and is linked to obesity development. However, the exact dynamic and regulation of eCBs in the hypothalamus during obesity progression remain ...
    • Hypothalamic regulation of obesity 

      Rodríguez-Rodríguez, Rosalía; Miralpeix Monclús, Cristina (International Journal of Molecular Sciences, 2021)
      Obesity has now reached pandemic proportions and represents a major socioeconomic and health problem in our societies. Up to now, obesity has been considered a medical issue only in high-income countries, ...
    • Identification of the ghrelin and cannabinoid CB2 receptor heteromer functionality and marked upregulation in striatal neurons from offspring of mice under a high-fat diet 

      Lillo, Jaume; Lillo, Alejandro; Zafra, David A.; Miralpeix Monclús, Cristina; Rivas-Santisteban, Rafael; Casals i Farré, Núria; Navarro, Gemma; Franco, Rafael (International Journal of Molecular Sciences, 2021)
      Cannabinoids have been reported as orexigenic, i.e., as promoting food intake that, among others, is controlled by the so-called “hunger” hormone, ghrelin. The aim of this paper was to look for functional ...
    • Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice 

      Soler Vázquez, M. Carmen; Romero, María del Mar; Todorcevic, Marijana; Delgado, Katia; Calatayud, Carles; Benitez Amaro, Aleyda; La Chica Lhoëst, Maria Teresa; Mera, Paula; Zagmutt, Sebastián; Bastías Pérez, Marianela; Ibeas, Kevin; Casals, Núria; Escolà Gil, Joan Carles; Llorente Cortés, Vicenta; Consiglio, Antonella; Serra, Dolors; Herrero, Laura (Metabolic Engineering, 2023-05)
      Obesity and its associated metabolic comorbidities are a rising global health and social issue, with novel therapeutic approaches urgently needed. Adipose tissue plays a key role in the regulation of ...
    • Integrated metabolomics, lipidomics, and genomics reveal the presence of a new biomarker, butanediol glucuronide, associated with the activation of Liver ketogenesis and lipid oxidation by tomato-based sofrito in obese rats 

      Rinaldi de Alvarenga, José Fernando; Garcia-Aloy, Mar; Ulaszewska, Maria; Zagmutt, Sebastián; Pérez-Montero, Marta; Vrhovsek, Urska; Lamuela-Raventos, Rosa M; Rodriguez-Rodriguez, Rosalia (Antioxidants, 2022)
      The increasing prevalence of obesity worldwide has promoted research on human metabolism and foods such as sofrito, a tomato and olive oil-based sauce from the Mediterranean diet, has shown beneficial ...
    • Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD 

      Weber, Minéia; Mera, Paula; Casas, Josefina; Salvador, Javier; Rodríguez, Amaia; Alonso, Sergio; Sebastián, David; Soler-Vázquez, M. Carmen; Montironi, Carla; Recalde, Sandra; Fucho, Raquel; Calderón-Domínguez, María; Mir, Joan Francesc; Bartrons, Ramon; Escola-Gil, Joan Carles; Sánchez-Infantes, David; Zorzano, Antonio; Llorente-Cortes, Vicenta; Casals i Farré, Núria; Valentí, Víctor; Frühbeck, Gema; Herrero Rodríguez, Laura; Serra, Dolors (Federation of American Societies for Experimental Biology, 2020)
      The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased drastically due to the global obesity pandemic but at present there are no approved therapies. Here, we aimed to revert high‐fat ...
    • New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes 

      Fosch, Anna; Zagmutt, Sebastián; Casals i Farré, Núria; Rodríguez-Rodríguez, Rosalía (International Journal of Molecular Sciences, 2021)
      Despite the substantial role played by the hypothalamus in the regulation of energy balance and glucose homeostasis, the exact mechanisms and neuronal circuits underlying this regulation remain poorly ...
    • Pomace olive oil concentrated in triterpenic acids restores vascular function, glucose tolerance and obesity progression in mice 

      Claro-Cala, Carmen Maria; Quintela, Jose Carlos; Pérez-Montero, Marta; Miñano, Javier; Alvarez de Sotomayor, María; Dolores Herrera, María; Rodríguez-Rodríguez, Rosalía (Nutrients, 2020-01)
      Pomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential ...
    • Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balance 

      Rodríguez-Rodríguez, Rosalía; Fosch, Anna; Garcia-Chica, Jesús; Zagmutt, Sebastián; Casals Farré, Nuria (Journal of Neuroendocrinology, 2023)
      Tackling the growing incidence and prevalence of obesity urgently requires uncovering new molecular pathways with therapeutic potential. The brain, and in particular the hypothalamus, is a major integrator ...