Now showing items 1-3 of 3

    • Hormone-control regions mediate steroid receptor–dependent genome organization 

      Le Dily, François; Vidal, Enrique; Cuartero, Yasmina; Quilez Oliete, Javier; Nacht, A. Silvina; Vicent, Guillermo P.; Carbonell-Caballero, José; Sharma, Priyanka; Villanueva-Cañas, José Luis; Ferrari, Roberto; De Llobet, Lara Isabel; Verde, Gaetano; Wright, Roni H.G.; Beato, Miguel (Genome Research, 2019)
      In breast cancer cells, some topologically associating domains (TADs) behave as hormonal gene regulation units, within which gene transcription is coordinately regulated in response to steroid hormones. ...
    • Hormone-induced repression of genes requires BRG1-mediated H1.2 deposition at target promoters 

      Nacht, Ana Silvina; Pohl, Andy; Zaurín Quer, Roser; Soronellas, Daniel; Quilez Oliete, Javier; SHARMA, PRIYANKA; Wright, Roni; Beato, Miguel; Vincent, Guillermo P. (The EMBO Journal, 2016)
      Eukaryotic gene regulation is associated with changes in chromatin compaction that modulate access to DNA regulatory sequences relevant for transcriptional activation or repression. Although much is ...
    • Signalling network of breast cancer cells in response to progesterone 

      Wright, Roni H.G.; Vastolo, Viviana; Quilez Oliete, Javier; Carbonell-Caballero, José; Beato, Miguel (BioRxiv, 2020)
      Breast cancer cells enter into the cell cycle following progestin exposure by the activation of signalling cascades involving a plethora of enzymes, transcription factors and co-factors that transmit ...