Browsing by Author "Quandt Herrera, Eva"

Now showing items 1-7 of 7

    • Atypical cyclin P regulates cancer cell stemness through activation of the WNT pathway 

      Sánchez‑Botet, Abril; Quandt Herrera, Eva; Masip, Núria; Escribá, Rubén; Novellasdemunt, Laura; Gasa Colom, Laura; Li, Vivian S. W.; Raya, Ángel; Clotet Erra, Josep; Ribeiro, Mariana P. C. (Cellular Oncology, 2021)
      Purpose: Cancer stem cells represent a cancer cell subpopulation that has been found to be associated with metastasis and chemoresistance. Therefore, it is vital to identify mechanisms regulating cancer ...

    • Atypical cyclins: the extended family portrait 

      Quandt Herrera, Eva; Ribeiro, Mariana P. C.; Clotet Erra, Josep (Cellular and Molecular Life Sciences, 2020)
      Regulation of cell division is orchestrated by cyclins, which bind and activate their catalytic workmates, the cyclin-dependent kinases (CDKs). Cyclins have been traditionally defined by an oscillating ...

    • Caracterización de complejos CDK-Ciclina atípicos humanos 

      Quandt Herrera, Eva (Date of defense: 2018-03-15)
      La desregulación en los mecanismos de control del ciclo celular es un evento indiscutiblemente asociado a la aparición de diversas patologías, entre las que destacan los procesos tumorales. Como principales ...

    • Functional genomics approaches to elucidate vulnerabilities of intrinsic and acquired chemotherapy resistance 

      Cetin, Ronay; Quandt Herrera, Eva; Kaulich, Manuel (Cells, 2021)
      Drug resistance is a commonly unavoidable consequence of cancer treatment that results in therapy failure and disease relapse. Intrinsic (pre-existing) or acquired resistance mechanisms can be drug-specific ...

    • Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex 

      Hernández Ortega, Sara; Sánchez Botet, Abril; Quandt Herrera, Eva; Masip, Núria; Gasa Colom, Laura; Verde, Gaetano; Jiménez Jiménez, Javier; Levin, Rebecca; Rugatanira, Florentine U.; Burlingame, Alma L.; Wolfgeher, Donald; P.C. Ribeiro, Mariana; Kron, Stephen J.; M. Shokat, Kevan; Clotet Erra, Josep (2019)
      CDK16 (also known as PCTAIRE1 or PCTK1) is an atypical member of the cyclin-dependent kinase (CDK) family that forms an active complex with cyclin Y (CCNY). Although both proteins have been recently ...

    • A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer 

      Gasa Colom, Laura; Sánchez Botet, Abril; Quandt Herrera, Eva; Hernández Ortega, Sara; Jiménez Jiménez, Javier; Carrasco García, Miguel Ángel; Simonetti, Sara; Kron, Stephen J.; P.C. Ribeiro, Mariana; Nadal, E; Villanueva, Alberto; Clotet Erra, Josep (2017-08-31)
      As lung cancer has increased to the most common cause of cancer death worldwide, prognostic biomarkers and efective targeted treatments remain lacking despite advances based on patients’ stratifcation. ...

    • The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration 

      Sánchez Botet, Abril; Gasa Colom, Laura; Quandt Herrera, Eva; Hernández Ortega, Sara; Jiménez Jiménez, Javier; Mezquita Mas, Pau; Carrasco García, Miguel Ángel; Kron, Stephen J.; Vidal, August; Villanueva, Alberto; P.C. Ribeiro, Mariana; Clotet Erra, Josep (2018-08-07)
      Colorectal cancer (CRC) is one of the most common cancers worldwide, with 8–10% of these tumours presenting a BRAF (V600E) mutation. Cyclins are known oncogenes deregulated in many cancers, but the role ...