Browsing by Author "Barneda-Zahonero, Bruna"
Now showing items 1-5 of 5
-
Bone morphogenetic protein-6 promotes cerebellar granule neurons survival by activation of the MEK/ERK/CREB pathway
Barneda-Zahonero, Bruna; Miñano Molina, Alfredo Jesús; Badiola, Nahuai; Fadó Andrés, Rut; Xifró Collsamata, Xavier; Saura, Carlos A.; Rodríguez Álvarez, José (2009-12-15)Bone morphogenetic proteins (BMPs) have been implicated in the generation and postnatal differentiation of cerebellar granule cells (CGCs). Here, we examined the eventual role of BMPs on the survival ... -
Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12
Badiola, Nahuai; Penas, Clara; Miñano Molina, Alfredo Jesús; Barneda-Zahonero, Bruna; Fadó Andrés, Rut; Sánchez-Opazo, G.; Comella, Joan X.; Sabrià, Josefa; Zhu, Chuanshuai; Blomgren, Klas; Casas, Caty; Rodríguez-Álvarez, José (Cell Death and Disease, 2011-04-28)Disturbance of calcium homeostasis and accumulation of misfolded proteins in the endoplasmic reticulum (ER) are considered contributory components of cell death after ischemia. However, the signal-transducing ... -
Nurr1 protein Is required for N-methyl-d-aspartic acid (NMDA) receptor-mediated neuronal survival
Barneda-Zahonero, Bruna; Servitja, Joan-Marc; Badiola, Nahuai; Miñano Molina, Alfredo Jesús; Fadó Andrés, Rut; Saura, Carlos A.; Rodríguez-Álvarez, José (Journal of Biological Chemistry, 2012-03-30)NMDA receptor (NMDAR) stimulation promotes neuronal survival during brain development. Cerebellar granule cells (CGCs) need NMDAR stimulation to survive and develop. These neurons differentiate and ... -
Soluble oligomers of amyloid-β peptide disrupt Membrane trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction
Miñano Molina, Alfredo Jesús; España, Judit; Martín, Elsa; Barneda-Zahonero, Bruna; Fadó Andrés, Rut; Solé, Montse; Trullás, Ramón; Saura, Carlos A.; Rodríguez-Álvarez, José (Journal of Biological Chemistry, 2011-08-05)β-Amyloid (Aβ), a peptide generated from the amyloid precursor protein, is widely believed to underlie the pathophysiology of Alzheimer disease (AD). Emerging evidences suggest that soluble Aβ oligomers ... -
X-linked Inhibitor of Apoptosis Protein negatively regulates neuronal differentiation through interaction with cRAF and Trk
Fadó Andrés, Rut; Moubarak, Rana S.; Miñano Molina, Alfredo Jesús; Barneda-Zahonero, Bruna; Valero, Jorge; Saura, Carlos A.; Moran, Julio; Comella, Joan X.; Rodríguez-Álvarez, José (Scientific Reports, 2013-08-09)X-linked Inhibitor of apoptosis protein (XIAP) has been classically identified as a cell death regulator. Here, we demonstrate a novel function of XIAP as a regulator of neurite outgrowth in neuronal ...